The Anti-Kickback Statute (1972) which prohibits clinicians and researchers from offering or accepting any payment to induce federal healthcare business, is an important legal rule pertinent to clinical studies.  When agreeing to participate in clinical trials, clinicians should be mindful of the risks and possible legal scrutiny under the Anti-Kickback Statute, and follow the guidance of the Pharmaceutical Research and Manufacturers of America to minimize their risk. (Clinical Leader)