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2021 Update

Clinical Research Currents has temporarily suspended publication.
Learn about our new clinical trials startup, Sparrow Search, connecting patients with clinical trials.

Amgen initiative to bring community practices into oncology clinical trials

www.amgen.com

June 2, 2019
Clinical trials, Oncology, Sites

About 80 percent of cancer patients in the U.S. are treated outside of an academic institute by a community oncologist. Amgen has launched Amgen Community Oncology Research Collaborators (ACORC), a new initiative that will provide community oncologists the opportunity to have their patients participate in clinical trials of investigational agents from Amgen’s pipeline. (Amgen)

Cancer drugs approved via accelerated pathway may not improve survival

www.raps.org

June 2, 2019
Clinical science, FDA, Oncology

Authors of a new study published in JAMA Internal Medicine research found that just one-fifth of confirmatory trials for cancer drug indications approved via FDA’s accelerated approval pathway demonstrated improvements in overall survival (OS).  Although improvement in surrogate measures may be acceptable for accelerated approval, confirmatory trials should verify the clinical benefits in terms of overall survival (OS) or quality of life. (Regulatory Focus)

North America leads the clinical trials market

finance.yahoo.com

May 27, 2019
Clinical trials, Oncology, Trends

The global clinical trials market size is expected to reach USD 6.89 billion by 2026, and one of the key drivers is the globalization of clinical trials. North America leads the market in terms of revenue share; Phase III trials are expected to dominate the market; and the oncology segment will grow the fastest. (Yahoo Finance)

Current Feature

Conducting pediatric oncology clinical trials: a coordinator’s perspective

May 10, 2019
Interview, Oncology, Sites

Tatsiana Verstak interviews Kathy Jackson, CRA at St. Jude Children’s Research Hospital, Memphis, TN Kathy Jackson has worked at St. Jude Children’s Research Hospital for 22 years, with 15 of those years in clinical research. Her background is in Health Information Management with a Master’s in Information Systems. She has Read more

Target cancer stem cells and revolutionize cancer treatment

www.independent.co.uk

March 2, 2019
Gene & cell therapy, Oncology

About 95-98% of new anti-cancer drugs fail phase III clinical trials. Most drugs are made to target “bulk” cancer cells, but not the root cause: the cancer stem cell.  New therapies that specifically target and eradicate these cancer stem cells are needed to prevent tumors from growing and spreading, and we may then be able to turn cancer into a manageable chronic disease. (INDEPENDENT)

Drug sponge could minimize side effects of cancer treatment

www.sciencedaily.com

February 18, 2019
Adverse events, Oncology

Catheters are used today to deliver drugs directly to tumors, but half of the drug can still escape to the rest of the body, causing side effects. Doctors treating liver cancer worked with chemical engineers to design an absorbent polymer-coated device that can be temporarily placed in the vein coming out of the liver to absorb unused chemotherapy drugs, potentially lowering the risk of side effects. (Science Daily)

Trials exclude patients with mental or psychiatric disorders

www.healio.com

February 2, 2019
Clinical trials, Oncology, Recruitment

According to the FDA, nearly 50% of investigational new drug applications excluded patients with mental or psychiatric disorders. Should cancer clinical trial eligibility regarding mental illness be relaxed? One viewpoint is that we should relax enrollment criteria and avoid unnecessary exclusion of patients with serious mental illness. (Healio)

National Cancer Institute expands eligibility criteria for trials

www.onclive.com

February 2, 2019
Clinical trials, Oncology, Recruitment

The National Cancer Institute (NCI) has revised its clinical trial protocols to expand access for previously excluded patients. The revisions expand access for potential participants with preexisting conditions in 4 categories, and patients under the age of 18 years. (OncLive)

ASCO, FDA recommend relaxing cancer trial eligibility criteria

www.medpagetoday.com

January 20, 2019
Clinical trials, Oncology, Recruitment

A new study found that physicians were less likely to offer clinical trial participation to patients with a comorbidity. The American Society of Clinical Oncology (ASCO), Friends of Cancer Research, and the FDA recently reviewed the comorbid conditions that are generally used in eligibility criteria to exclude patients, and recommended that many be modified or liberalized, which could be necessary to improve study participation. (MEDPAGE TODAY)

How in silico trials are making personalized medicine a reality

WWW.OUTSOURCING-PHARMA.COM

January 11, 2019
AI & Machine Learning, Oncology, Precision Medicine

The biopharma industry is on the precipice of making personalized medicine a reality with access to massive amounts of data, computing power, and artificial intelligence to run in silico clinical trials, says GNS Healthcare CEO. (outsourcing-pharma.com)

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